Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.73 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.69 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3838048 | 1.00 | ALDH1A1 (0.75) | ALDH1A1LMNACDK5CDK5R1RAB9A | |
| SCHEMBL13960177 | 0.95 | ALDH1A1 (0.84) | ALDH1A1LMNACDK5CDK5R1RAB9A | |
| SCHEMBL13960176 | 0.95 | ALDH1A1 (0.84) | ALDH1A1LMNACDK5CDK5R1RAB9A | |
| SCHEMBL392625 | 0.91 | ALDH1A1 (0.82) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 | |
| SCHEMBL14758329 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 | |
| SCHEMBL10133036 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 | |
| SCHEMBL8008513 | 0.85 | CDK5 (1.00) | ALDH1A1LMNACDK5CDK5R1RAB9A | |
| SCHEMBL1656898 | 0.84 | L3MBTL1 (1.00) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 | |
| SCHEMBL14340623 | 0.84 | ALDH1A1 (0.73) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 | |
| SCHEMBL7285179 | 0.84 | ALDH1A1 (0.73) | ALDH1A1LMNARAB9AL3MBTL1ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124605-B2 | Compositions and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124605-B2 | Compositions and methods for modulating a kinase cascade | KINEX PHARMACEUTICALS, LLC (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | OAKTREE FUND ADMINISTRATION, LLC | 2009-06-11 | — | — | US | disclosed |
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | OAKTREE FUND ADMINISTRATION, LLC | 2009-06-11 | — | — | US | disclosed |
| WO-2009009041-A2 | COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2009-01-15 | — | — | WO | disclosed |
| US-4013618-A | NITROGEN-CONTAINING STABILIZER | TOYOBO CO., LTD. (JA) | 1977-03-22 | — | — | US | disclosed |
| US-3957905-A | HALOGENATED BISPHENYL COMPOUND, ANTIMONY COMPOUND | TOYO BOSEKI KABUSHIKI KAISHA (JA) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149510-A1 | Compositions and methods for modulating a kinase cascade | MAP3K6, MAP3K4, MAP3K3 | ALDH1A1 4811/4885LMNA 2046/4885CDK5 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.