Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 3/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10114882 | 1.00 | NAMPT (0.49) | NAMPTCRHBPCRHR2KMT2AJAK2 | |
| SCHEMBL14424644 | 1.00 | NAMPT (0.49) | NAMPTCRHBPCRHR2KMT2AJAK2 | |
| SCHEMBL13204379 | 1.00 | NAMPT (0.49) | NAMPTCRHBPCRHR2KMT2AJAK2 | |
| SCHEMBL14627688 | 0.89 | HSD17B10 (0.51) | JAK2ALDH1A1HPGDSMN1; SMN2MGLL | |
| SCHEMBL10114892 | 0.89 | HSD17B10 (0.51) | JAK2ALDH1A1HPGDSMN1; SMN2MGLL | |
| SCHEMBL10133458 | 0.89 | HSD17B10 (0.51) | JAK2ALDH1A1HPGDSMN1; SMN2MGLL | |
| SCHEMBL13204378 | 0.89 | HSD17B10 (0.51) | JAK2ALDH1A1HPGDSMN1; SMN2MGLL | |
| SCHEMBL10116074 | 0.86 | NAMPT (0.57) | NAMPTCRHBPCRHR2KMT2AALDH1A1 | |
| SCHEMBL10134200 | 0.86 | NAMPT (0.57) | NAMPTCRHBPCRHR2KMT2AALDH1A1 | |
| SCHEMBL14627639 | 0.86 | CRHBP (0.51) | NAMPTCRHBPCRHR2KMT2AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7781461-B2 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2010-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | NAMPT 2350/4885CRHBP 256/4885CRHR2 13/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | NAMPT 2832/4885CRHBP 247/4885CRHR2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.