Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | LMNA | P02545 | 8/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10134747 | 0.84 | CASP1 (0.62) | KDM4EALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL12359371 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL12024781 | 0.82 | LMNA (0.62) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL10134740 | 0.81 | HPGD (0.49) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL27680029 | 0.78 | LMNA (1.00) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL12391554 | 0.78 | LMNA (0.66) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL5321616 | 0.75 | HPGD (0.69) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL249932 | 0.75 | HPGD (0.58) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL11829949 | 0.74 | LMNA (0.72) | KDM4EALDH1A1LMNAHTTRAB9A | |
| SCHEMBL6450710 | 0.73 | TACR3 (0.76) | KDM4EALDH1A1LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703770-B2 | Pyridazine carboxamide orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120046289-A1 | Pyridazine Carboxamide Orexin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046289-A1 | Pyridazine Carboxamide Orexin Receptor Antagonists | HCRTR2, HCRTR1, NPY5R | KDM4E 1824/4885ALDH1A1 3353/4885LMNA 2800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.