⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750352 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL15545966 | 0.98 | ALOX5 (0.40) | — | |
| SCHEMBL1101155 | 0.78 | — | — | |
| SCHEMBL5176546 | 0.78 | ALOX5 (0.38) | — | |
| SCHEMBL6731353 | 0.74 | — | — | |
| SCHEMBL4950283 | 0.74 | — | — | |
| SCHEMBL1696274 | 0.74 | — | — | |
| SCHEMBL21495020 | 0.74 | — | — | |
| SCHEMBL22774795 | 0.74 | — | — | |
| SCHEMBL1696175 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173392-B2 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-05-08 | — | — | US | disclosed |
| US-20120101006-A1 | Methods and Compositions for the Production of Orthogonal tRNA-Aminoacyl tRNA Synthetase Pairs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-04-26 | — | — | US | disclosed |
| US-20090227002-A1 | Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs | THE SCRIPPS RESEARCH INSTITUTE and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-09-10 | — | — | US | disclosed |
| US-20090068717-A1 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080227152-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-18 | — | — | US | disclosed |