Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10141845 | 0.75 | TSHR (0.42) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL4625850 | 0.71 | TSHR (0.61) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL16302043 | 0.71 | TSHR (0.61) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL4625705 | 0.71 | CYP4F2 (0.53) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL11918298 | 0.71 | TSHR (0.41) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL27389387 | 0.70 | MAOB (0.45) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL18948389 | 0.70 | TSHR (0.40) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL8127146 | 0.69 | CYP4F2 (0.55) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL609694 | 0.69 | CASP1 (0.43) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A | |
| SCHEMBL236240 | 0.68 | CYP4F2 (0.57) | TSHRCYP4F2CYP4A11BAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040950-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040950-A1 | ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE | PIK3CD, PIK3CA, PIK3R5 | TSHR 4086/4885CYP4F2 3909/4885CYP4A11 2576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.