SCHEMBL10143500

Cc1cc(=O)[nH]c2cc(NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12

nearest known ligand 0.55

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	SIRT5	Q9NXA8	2/20	0.42

▸	MDM2	Q00987	1/20	0.41

▸	CA1	P00915	1/20	0.41

▸	CA2	P00918	1/20	0.41

▸	PTPN1	P18031	5/20	0.40

▸	GRB2	P62993	1/20	0.40

▸	TPSAB1	Q15661	1/20	0.39

▸	TLR2	O60603	1/20	0.39

▸	TLR1	Q15399	1/20	0.39

▸	HDAC4	P56524	1/20	0.38

▸	HDAC1	Q13547	1/20	0.38

▸	KMT2A	Q03164	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10144432	0.95	CA1 (0.45)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10143496	0.93	CA1 (0.42)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10144419	0.90	MDM2 (0.41)	MDM2CA1CA2TPSAB1
SCHEMBL10144194	0.90	MDM2 (0.39)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10143498	0.90	MDM2 (0.41)	SIRT5MDM2CA1CA2KMT2A
SCHEMBL10143543	0.89	CTSS (0.40)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10143502	0.89	TLR2 (0.45)	SIRT5PTPN1GRB2TPSAB1TLR2
SCHEMBL10144152	0.88	MDM2 (0.38)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10143509	0.88	CACNA1B (0.39)	SIRT5MDM2CA1CA2TPSAB1
SCHEMBL10144130	0.88	CA1 (0.39)	SIRT5MDM2CA1CA2TPSAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012009258-A2	PEPTIDOMIMETIC GALANIN RECEPTOR MODULATORS	ROBERTS EDWARD (US)	2012-01-19	—	—	WO	disclosed