SCHEMBL10143518

Cc1cc(=O)[nH]c2cc(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)OC3CCCCC3)NC(=O)OCC3c4ccccc4-c4ccccc43)ccc12

nearest known ligand 0.43

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	TLR2	O60603	2/20	0.43

▸	HDAC4	P56524	3/20	0.38

▸	MEF2D	Q14814	3/20	0.38

▸	EP300	Q09472	1/20	0.38

▸	F10	P00742	2/20	0.37

▸	PRSS1	P07477	1/20	0.37

▸	PTPN1	P18031	5/20	0.36

▸	TPSAB1	Q15661	1/20	0.35

▸	PRCP	P42785	1/20	0.35

▸	GRB2	P62993	1/20	0.34

▸	CACNA1B	Q00975	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10144324	0.91	TLR2 (0.44)	TLR2HDAC4MEF2DEP300PTPN1
SCHEMBL10143509	0.90	CACNA1B (0.39)	TLR2HDAC4F10PRSS1TPSAB1
SCHEMBL10144446	0.89	TLR2 (0.43)	TLR2HDAC4MEF2DEP300PTPN1
SCHEMBL10143502	0.87	TLR2 (0.45)	TLR2HDAC4MEF2DEP300PTPN1
SCHEMBL10143499	0.86	TLR2 (0.45)	TLR2HDAC4MEF2DEP300PTPN1
SCHEMBL10143401	0.84	TLR2 (0.46)	TLR2HDAC4PTPN1
SCHEMBL10143497	0.84	TLR2 (0.42)	TLR2PTPN1TPSAB1GRB2
SCHEMBL10144428	0.84	TLR2 (0.42)	TLR2HDAC4MEF2DEP300PTPN1
SCHEMBL10144426	0.83	TLR2 (0.42)	TLR2HDAC4MEF2DPTPN1TPSAB1
SCHEMBL10144208	0.82	TLR2 (0.40)	TLR2HDAC4MEF2DEP300TPSAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012009258-A2	PEPTIDOMIMETIC GALANIN RECEPTOR MODULATORS	ROBERTS EDWARD (US)	2012-01-19	—	—	WO	disclosed