Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 5/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977195 | 0.98 | MAPK13 (0.52) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL17014412 | 0.97 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL456621 | 0.92 | MAPK13 (0.55) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL19566591 | 0.92 | SCN10A (0.52) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL7600347 | 0.84 | SCN10A (0.43) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL16577349 | 0.83 | SSTR3 (0.48) | SCN10AHPGDSTTKSSTR3KCNH2 | |
| SCHEMBL17281351 | 0.83 | SCN10A (0.48) | SCN10AHPGDSTTKSSTR3KCNH2 | |
| SCHEMBL17281352 | 0.82 | HPGDS (0.62) | SCN10AHPGDSTTKSSTR3KCNH2 | |
| SCHEMBL16577384 | 0.81 | RPS6KB1 (0.46) | MAPK13MAPK12MAPK11MAPK14SCN10A | |
| SCHEMBL16577375 | 0.81 | MAPK13 (0.51) | MAPK13MAPK12MAPK11MAPK14SCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038501-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. | 2015-02-05 | — | — | US | disclosed |
| US-8865756-B2 | Inhibitors of HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130296311-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2013-11-07 | — | — | US | disclosed |
| US-20120115855-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296311-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | MAPK13 2347/4885MAPK12 2259/4885MAPK11 2681/4885 |
| US-20150038501-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | MAPK13 2347/4885MAPK12 2259/4885MAPK11 2681/4885 |
| US-20120115855-A1 | INHIBITORS OF HCV NS5A | HAVCR2, MAVS, EIF2AK2 | MAPK13 2347/4885MAPK12 2259/4885MAPK11 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.