SCHEMBL10145544

SCHEMBL10145544

CNc1ccc2c(-c3ccccc3C(=O)O)c3ccc(=O)cc-3oc2c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ USP2 O75604 4/20 0.55
▸ L3MBTL1 Q9Y468 1/20 0.55
▸ DNASE1L3 Q13609 1/20 0.52
▸ PRMT1 Q99873 1/20 0.52
▸ POLB P06746 3/20 0.51
▸ MEN1 O00255 2/20 0.51
▸ KMT2A Q03164 2/20 0.51
▸ ATM Q13315 2/20 0.51
▸ PLEC Q15149 1/20 0.51
▸ CA9 Q16790 10/20 0.50
▸ CA1 P00915 9/20 0.50
▸ CA2 P00918 9/20 0.50
▸ ALPL P05186 1/20 0.48
▸ ALPI P09923 1/20 0.48
▸ ALPG P10696 1/20 0.48
▸ CA12 O43570 3/20 0.48
▸ ABCB1 P08183 1/20 0.47
▸ FTO Q9C0B1 2/20 0.47
▸ CA14 Q9ULX7 2/20 0.46
▸ CFTR P13569 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14350757 0.88 ABCB1 (0.61) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL6056016 0.86 ABCB1 (0.45) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL12697372 0.86 ABCB1 (0.45) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL609855 0.86 ABCB1 (0.45) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL12060569 0.86 USP2 (0.72) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL10060277 0.85 POLB (0.59) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL107875 0.84 USP2 (0.76) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL29781098 0.84 USP2 (0.76) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL29591827 0.84 USP2 (0.76) USP2L3MBTL1DNASE1L3PRMT1POLB
SCHEMBL8947940 0.84 USP2 (0.58) USP2L3MBTL1DNASE1L3PRMT1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2250177-B1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LTD (CN) 2014-06-18 — — EP disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
WO-2009121247-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES ROS1, LPO, HMOX1 USP2 921/4885L3MBTL1 695/4885DNASE1L3 419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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