Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.57 |
| ▸ | PARG | Q86W56 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146658 | 0.89 | GRM2 (0.50) | GRM2PARG | |
| SCHEMBL10146643 | 0.87 | GRM2 (0.48) | GRM2PARG | |
| SCHEMBL626738 | 0.86 | GRM2 (0.54) | GRM2PARGGRIN1GRIN2B | |
| SCHEMBL10146010 | 0.85 | PARG (0.39) | GRM2PARGTRIM24GRIN1GRIN2B | |
| SCHEMBL10146656 | 0.85 | GRM2 (0.59) | GRM2PARGTRIM24GRIN1GRIN2B | |
| SCHEMBL10146360 | 0.82 | GRM2 (0.64) | GRM2PARGTRIM24NPC1RAB9A | |
| SCHEMBL10146341 | 0.82 | GRM2 (0.77) | GRM2PARGTRIM24NPC1RAB9A | |
| SCHEMBL10146389 | 0.81 | GRM2 (0.59) | GRM2PARGTRIM24GRIN1GRIN2B | |
| SCHEMBL627826 | 0.79 | GRM2 (0.56) | GRM2PARGTRIM24 | |
| SCHEMBL10146388 | 0.78 | GRM2 (0.55) | GRM2GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |