Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.48 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 8/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146658 | 0.93 | GRM2 (0.50) | GRM2SCN9APARG | |
| SCHEMBL10145817 | 0.87 | GRM2 (0.57) | GRM2PARG | |
| SCHEMBL14992886 | 0.87 | GRM2 (0.46) | GRM2PTAFRHTR2BDRD1 | |
| SCHEMBL20496338 | 0.85 | GRM2 (0.53) | GRM2PTAFRHTR2BDRD1PARG | |
| SCHEMBL20496337 | 0.82 | GRM2 (0.42) | GRM2PTAFRHTR2BDRD1 | |
| SCHEMBL626918 | 0.80 | GRM2 (0.48) | GRM2DRD1PARG | |
| SCHEMBL10146378 | 0.78 | GRM2 (0.61) | GRM2PARG | |
| SCHEMBL10146645 | 0.78 | GRM2 (0.49) | GRM2PTAFRHTR2BPARG | |
| SCHEMBL10146668 | 0.75 | GRM2 (0.70) | GRM2PARG | |
| SCHEMBL10145959 | 0.75 | GRM2 (0.72) | GRM2SCN9APARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |