Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.64 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146341 | 0.91 | GRM2 (0.77) | GRM2TRIM24PARGSMN1; SMN2NPC1 | |
| SCHEMBL626728 | 0.87 | GRM2 (0.60) | GRM2TRIM24PARGGAA | |
| SCHEMBL10146656 | 0.86 | GRM2 (0.59) | GRM2TRIM24PARGSMN1; SMN2NPC1 | |
| SCHEMBL10146311 | 0.85 | GRM2 (0.78) | GRM2PARGALDH1A1GAAMAPT | |
| SCHEMBL10146684 | 0.84 | GRM2 (0.44) | GRM2TRIM24SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10146345 | 0.83 | PARG (0.42) | GRM2TRIM24PARGSMN1; SMN2ALDH1A1 | |
| SCHEMBL10146364 | 0.83 | GRM2 (0.53) | GRM2PARG | |
| SCHEMBL10146661 | 0.82 | GRM2 (0.55) | GRM2PARG | |
| SCHEMBL10145817 | 0.82 | GRM2 (0.57) | GRM2TRIM24PARGSMN1; SMN2NPC1 | |
| SCHEMBL10146389 | 0.82 | GRM2 (0.59) | GRM2TRIM24PARGSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |