Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 11/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145836 | 0.86 | GRM2 (0.39) | P2RX3TRIM24GRM2AXL | |
| SCHEMBL10146391 | 0.85 | TRIM24 (0.40) | PARGP2RX3TRIM24GRM2AXL | |
| SCHEMBL10146625 | 0.82 | GRM2 (0.36) | P2RX3TRIM24GRM2AXL | |
| SCHEMBL10145839 | 0.82 | PIK3CA (0.44) | PARGGRM2AXL | |
| SCHEMBL14992370 | 0.81 | PARG (0.40) | PARGP2RX3GRM2 | |
| SCHEMBL10146620 | 0.79 | POLB (0.35) | PARGP2RX3AXL | |
| SCHEMBL10146671 | 0.78 | PARG (0.51) | PARGGRM2 | |
| SCHEMBL10146007 | 0.74 | GRM2 (0.43) | PARGGRM2 | |
| SCHEMBL10146645 | 0.73 | GRM2 (0.49) | PARGGRM2 | |
| SCHEMBL10146006 | 0.72 | PARG (0.40) | PARGTRIM24GRM2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |