Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.58 |
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146342 | 0.91 | GRM2 (0.47) | GRM2PARGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10146344 | 0.90 | METAP2 (0.48) | GRM2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14992426 | 0.84 | GRM2 (0.56) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL14993200 | 0.84 | GRM2 (0.56) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL14992658 | 0.84 | GRM2 (0.58) | GRM2PARGMETAP2 | |
| SCHEMBL10146668 | 0.83 | GRM2 (0.70) | GRM2PARGMETAP2 | |
| SCHEMBL10146655 | 0.83 | GRM2 (0.48) | GRM2PARGCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10145981 | 0.83 | CYP11B1 (0.39) | GRM2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10146361 | 0.82 | GRM2 (0.62) | GRM2PARGPTAFRHTR2B | |
| SCHEMBL14992270 | 0.82 | GRM2 (0.56) | GRM2PARGPTAFRHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |