Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 3/20 | 0.47 |
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146344 | 0.92 | METAP2 (0.48) | GRM2METAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10145979 | 0.91 | GRM2 (0.58) | GRM2METAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14992455 | 0.85 | GRM2 (0.46) | GRM2METAP2GRIN1GRIN2BBCL6 | |
| SCHEMBL10145981 | 0.81 | CYP11B1 (0.39) | GRM2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14992426 | 0.80 | GRM2 (0.56) | GRM2GRIN1GRIN2BPARG | |
| SCHEMBL10146644 | 0.80 | GRM2 (0.52) | GRM2CYP11B2GRIN1GRIN2B | |
| SCHEMBL14992270 | 0.78 | GRM2 (0.56) | GRM2GRIN1GRIN2BPARG | |
| SCHEMBL14992658 | 0.78 | GRM2 (0.58) | GRM2METAP2GRIN1GRIN2BPARG | |
| SCHEMBL14992498 | 0.77 | GRM2 (0.44) | GRM2METAP2GRIN1GRIN2B | |
| SCHEMBL14993200 | 0.76 | GRM2 (0.56) | GRM2PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |