Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976482 | 1.00 | ADAMTS5 (0.33) | ADAMTS5PLA2G7HCAR3HCAR2 | |
| SCHEMBL979166 | 1.00 | ADAMTS5 (0.33) | ADAMTS5PLA2G7HCAR3HCAR2 | |
| SCHEMBL979168 | 1.00 | ADAMTS5 (0.33) | ADAMTS5PLA2G7HCAR3HCAR2 | |
| SCHEMBL976480 | 1.00 | ADAMTS5 (0.33) | ADAMTS5PLA2G7HCAR3HCAR2 | |
| SCHEMBL976484 | 1.00 | ADAMTS5 (0.33) | ADAMTS5PLA2G7HCAR3HCAR2 | |
| SCHEMBL977281 | 0.78 | DUT (0.30) | — | |
| SCHEMBL977283 | 0.78 | DUT (0.30) | — | |
| SCHEMBL977284 | 0.78 | DUT (0.30) | — | |
| SCHEMBL12028357 | 0.77 | CALCRL (0.36) | HCAR3HCAR2 | |
| SCHEMBL976575 | 0.72 | ADAMTS5 (0.34) | ADAMTS5HCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271346-A2 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009120652-A2 | MONOCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-10-01 | — | — | WO | disclosed |