Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541322 | 0.93 | OPRL1 (0.41) | P2RY1RXRARXRBRXRGOPRL1 | |
| SCHEMBL541323 | 0.91 | P2RY1 (0.38) | P2RY1RXRARXRBRXRGOPRL1 | |
| SCHEMBL6523323 | 0.87 | PDE4B (0.44) | P2RY1OPRL1PDE4BKDM4EALDH1A1 | |
| SCHEMBL12796019 | 0.83 | RXRA (0.43) | P2RY1RXRARXRBRXRGOPRL1 | |
| SCHEMBL12795984 | 0.81 | ALDH1A1 (0.50) | P2RY1RXRARXRBRXRGHCRTR1 | |
| SCHEMBL12796505 | 0.69 | TSHR (0.48) | KDM4EALDH1A1NR1H2NFKB1NFKB2 | |
| SCHEMBL12796342 | 0.68 | AVPR1A (0.46) | OPRL1 | |
| SCHEMBL10145795 | 0.68 | NR1H2 (0.43) | P2RY1OPRL1KDM4EALDH1A1NR1H2 | |
| SCHEMBL12796228 | 0.67 | NR1H2 (0.43) | OPRL1KDM4EALDH1A1NR1H2NFKB1 | |
| SCHEMBL12796510 | 0.67 | NR1H2 (0.45) | P2RY1RXRARXRBRXRGOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415765-A1 | PYRIMIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |