Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 4/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146339 | 0.93 | PARG (0.43) | PARGGRM2TRIM24ICMTALDH1A1 | |
| SCHEMBL625527 | 0.92 | GRM2 (0.51) | PARGGRM2TRIM24ICMTSMN1; SMN2 | |
| SCHEMBL10145997 | 0.88 | PARG (0.42) | PARGGRM2TRIM24ICMTMEN1 | |
| SCHEMBL626276 | 0.87 | PARG (0.41) | PARGGRM2TRIM24P2RX3 | |
| SCHEMBL10146338 | 0.87 | GRIN1 (0.48) | PARGGRM2TRIM24ICMTGRIN1 | |
| SCHEMBL10146006 | 0.86 | PARG (0.40) | PARGGRM2TRIM24ICMTBACE1 | |
| SCHEMBL10146348 | 0.86 | GRM2 (0.43) | PARGGRM2TRIM24ICMTALDH1A1 | |
| SCHEMBL626976 | 0.84 | PARG (0.41) | PARGGRM2TRIM24MAPTP2RX3 | |
| SCHEMBL10146360 | 0.83 | GRM2 (0.64) | PARGGRM2TRIM24ALDH1A1SMN1; SMN2 | |
| SCHEMBL624925 | 0.83 | GRM2 (0.46) | PARGGRM2TRIM24ICMTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |