SCHEMBL1014701

SCHEMBL1014701

O=c1ccnnc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.48
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HTT P42858 2/20 0.36
LMNA P02545 2/20 0.36
TGFBR1 P36897 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
PAX8 Q06710 1/20 0.35
PDPK1 O15530 1/20 0.35
CA12 O43570 1/20 0.35
PARP1 P09874 1/20 0.35
ALOX15 P16050 1/20 0.35
CA9 Q16790 1/20 0.35
TNKS2 Q9H2K2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6265298 0.98 GPR3 (0.46) GPR3ALDH1A1SMN1; SMN2CYP1A2CYP2C19
SCHEMBL7446614 0.74 GPR3 (0.48) GPR3ALDH1A1SMN1; SMN2CYP1A2CYP2C19
Benzonaphthyridine SCHEMBL11311822 0.72 GPR3 (0.58) GPR3ALDH1A1SMN1; SMN2CYP1A2MAOA
SCHEMBL1248587 0.71 MAPT (0.58) ALDH1A1SMN1; SMN2CYP1A2MEN1KMT2A
SCHEMBL25095968 0.70 CYP1A2 (0.44) GPR3ALDH1A1CYP1A2CYP2C19MAOA
SCHEMBL22045624 0.70 GPR3 (0.54) GPR3ALDH1A1SMN1; SMN2CYP1A2CYP2C19
SCHEMBL276368 0.70 GPR3 (0.37) GPR3
SCHEMBL11270034 0.69 MAPT (0.48) ALDH1A1SMN1; SMN2CYP1A2MEN1KMT2A
SCHEMBL13859950 0.68 MAPT (0.54) ALDH1A1CYP1A2MEN1KMT2AHTT
SCHEMBL7904537 0.68 PARP1 (0.42) ALDH1A1CYP1A2CYP2C19MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979658-B Preparation method of flumazenil 南湖实验室 2022-05-31 CN claimed
US-8063204-B2 Benzothiazole and benzoxazole linked pyrrolo[2,1-c] [1, 4] benzodiazepine hybrids as novel antitumour agents and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2011-11-22 US claimed
EP-2350085-A1 QUINAZOLINONE LINKED PYRROLOÝ2,1 -C¨Ý1.4¨BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF Council Of Scientific & Industrial Research (IN) 2011-08-03 EP claimed
WO-2010058416-A1 QUINAZOLINONE LINKED PYRROLO[2,1 -C][1.4]BENZODIAZEPINE HYBRIDS AS POTENTIAL ANTICANCER AGENTS AND PROCESS FORTHE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2010-05-27 WO claimed
EP-2061795-A2 PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AND A PROCESS FOR THE PREPARATION THEREOF Council Of Scientific&industrial Research (IN) 2009-05-27 EP claimed
WO-2008020455-A2 PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2008-02-21 WO claimed
WO-2008020456-A2 PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRIDS AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2008-02-21 WO claimed
WO-2007054954-A1 A NOVEL PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRID AND A PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2007-05-18 WO claimed
WO-2005089515-A9 METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES BRIGHAM & WOMENS HOSPITAL (US) 2006-01-26 WO claimed
WO-2005089515-A2 METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2005-09-29 WO claimed
EP-1196412-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS Bristol-Myers Squibb Pharma Company (US) 2002-04-17 EP claimed
WO-2001005784-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR Xa INHIBITORS BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2001-01-25 WO claimed
EP-0987266-A1 BIPHENYL DERIVATIVES AND MEDICINAL COMPOSITIONS Wakamoto Pharmaceutical Co., Ltd. (JP) 2000-03-22 EP claimed
EP-0393604-A2 6,11-Dihydro-5H-pyrido(2,3-b)(1,5,)benzodiazepin-5-ones and thiones and their use in the prevention or treatment of AIDS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 1990-10-24 EP claimed
JP-54090195-A None JP disclosed
US-20260137700-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE SK BIOPHARMACEUTICALS CO LTD (KR) 2026-05-21 US disclosed
US-20250216392-A1 NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER SANOFI-AVENTIS (FR) 2025-07-03 US disclosed
JP-S5490195-A NOVEL BENZODIAZEPINE COMPOUND GREEN CROSS CORP:THE 1979-07-17 JP disclosed
US-4133809-A DEPRESSANTS, TRANQUILIZERS, SEDATIVES, GROWTH PROMOTERS, ANTICONVULSANTS, MUSCLE RELAXANTS E. R. SQUIBB & SONS, INC. (US) 1979-01-09 US disclosed
US-4111934-A MUSCLE RELAXANT, ANTICONVULSANT, SEDATIVE HOFFMANN-LA ROCHE INC. (US) 1978-09-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250216392-A1 NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER CD38, MCL1, CD2 GPR3 1472/4885ALDH1A1 2209/4885SMN1; SMN2 1968/4885
US-20260137700-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE PRMT5, PRMT1, PRMT6 GPR3 2326/4885ALDH1A1 3485/4885SMN1; SMN2 4165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.