Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | TMPRSS4 | Q9NRS4 | 4/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.30 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17141748 | 0.73 | MEN1 (0.43) | PTGS2GAANQO2MEN1KMT2A | |
| SCHEMBL320481 | 0.67 | CES2 (0.52) | MEN1KMT2ACES2TMPRSS4NOTUM | |
| SCHEMBL30062195 | 0.67 | CES2 (0.52) | MEN1KMT2ACES2TMPRSS4NOTUM | |
| SCHEMBL25400369 | 0.65 | GAA (0.46) | PTGS2GAANQO2MEN1KMT2A | |
| SCHEMBL29547954 | 0.65 | GAA (0.46) | PTGS2GAANQO2MEN1KMT2A | |
| SCHEMBL14754478 | 0.65 | NQO2 (0.38) | PTGS2GAANQO2MEN1KMT2A | |
| SCHEMBL10148598 | 0.64 | MAPT (0.35) | NQO2MEN1KMT2ACFTRKDM4E | |
| SCHEMBL28836879 | 0.64 | CES2 (0.47) | NQO2MEN1KMT2ACES2TMPRSS4 | |
| SCHEMBL27395327 | 0.64 | CES2 (0.52) | MEN1KMT2ACES2TMPRSS4CFTR | |
| SCHEMBL20259156 | 0.63 | CES2 (0.40) | GAAMEN1KMT2ACES2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004706-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-12 | — | — | WO | disclosed |