Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.60 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495770 | 0.86 | MCHR1 (0.65) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL10148843 | 0.84 | BACE1 (0.60) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8812119 | 0.78 | MCHR1 (0.57) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL660567 | 0.78 | MCHR1 (0.57) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL2993642 | 0.77 | OPRL1 (0.55) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL7841441 | 0.75 | MCHR1 (0.59) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8209542 | 0.75 | BACE1 (0.67) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9494295 | 0.75 | BACE1 (1.00) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9494403 | 0.75 | OPRL1 (0.53) | BACE1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL13209597 | 0.75 | OPRL1 (0.53) | BACE1OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114887-B2 | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease | Merck, Sharp & Dohme Corp. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20070197571-A1 | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer' s disease | MERCK SHARP & DOHME LLC | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197571-A1 | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzheimer' s disease | BACE1, BACE2, APP | BACE1 1/4885OPRL1 1765/4885OPRM1 4346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.