Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495702 | 0.83 | BDKRB2 (0.47) | OPRL1OPRM1OPRD1OPRK1ENPP2 | |
| SCHEMBL14560586 | 0.83 | MCHR1 (0.53) | OPRL1OPRM1OPRD1OPRK1BACE1 | |
| SCHEMBL18961832 | 0.79 | ENPP2 (0.43) | OPRL1OPRM1OPRD1ENPP2SIGMAR1 | |
| SCHEMBL8809939 | 0.78 | MCHR1 (0.54) | OPRL1OPRM1OPRD1OPRK1BACE1 | |
| SCHEMBL9495770 | 0.77 | MCHR1 (0.65) | OPRL1OPRM1OPRD1OPRK1BACE1 | |
| SCHEMBL10734152 | 0.76 | DRD2 (0.65) | OPRL1OPRM1OPRD1OPRK1CYP3A4 | |
| SCHEMBL9495219 | 0.76 | HSD17B10 (0.49) | OPRM1ENPP2CYP3A4HSD17B10SIGMAR1 | |
| SCHEMBL2993642 | 0.76 | OPRL1 (0.55) | OPRL1OPRM1OPRD1OPRK1BACE1 | |
| Hydrochloric Acid SCHEMBL9494287 | 0.75 | HSD17B10 (0.48) | OPRM1ENPP2CYP3A4HSD17B10SIGMAR1 | |
| SCHEMBL10148844 | 0.75 | BACE1 (0.60) | OPRL1OPRM1OPRD1OPRK1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221675-A | Aza-spirocyclic compounds that enhance cholinergic neurotransmission | ABBOTT LABORATORIES (US) | 1993-06-22 | — | — | US | disclosed |