Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.44 |
| ▸ | BRAF | P15056 | 7/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46894 | 0.87 | LCK (0.51) | LCKMAPK14RXFP1TRPV4BRAF | |
| SCHEMBL46512 | 0.79 | SLC34A2 (0.56) | LCKMAPK14TRPV4BRAFRAF1 | |
| SCHEMBL15433035 | 0.78 | DGAT1 (0.45) | LCKMAPK14RXFP1KDR | |
| SCHEMBL46988 | 0.77 | SLC34A2 (0.53) | LCKMAPK14TRPV4BRAFRAF1 | |
| SCHEMBL15957436 | 0.77 | LCK (0.43) | LCKMAPK14RXFP1TRPV4BRAF | |
| SCHEMBL16691165 | 0.77 | SLC34A2 (0.46) | LCKMAPK14TRPV4BRAFKDR | |
| SCHEMBL15432551 | 0.76 | SLC34A2 (0.59) | LCKMAPK14TRPV4BRAFRAF1 | |
| SCHEMBL15444404 | 0.76 | TRPV4 (0.43) | LCKMAPK14RXFP1TRPV4BRAF | |
| SCHEMBL46994 | 0.75 | SLC34A2 (0.52) | LCKMAPK14TRPV4BRAFRAF1 | |
| SCHEMBL10225092 | 0.74 | ALK (0.46) | LCKMAPK14TRPV4BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006474-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |