Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985776 | 0.88 | OPRK1 (0.50) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL2264662 | 0.87 | OPRK1 (0.53) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL2264868 | 0.87 | OPRK1 (0.53) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL2264478 | 0.86 | OPRK1 (0.52) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL11964613 | 0.86 | OPRK1 (0.62) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL2263970 | 0.85 | OPRK1 (0.49) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL605960 | 0.85 | OPRK1 (0.51) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL607292 | 0.84 | OPRK1 (0.53) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL29410184 | 0.84 | OPRK1 (0.54) | OPRK1LMNAPDE3AHDAC3HDAC6 | |
| SCHEMBL1687457 | 0.84 | OPRK1 (0.54) | OPRK1LMNAPDE3AHDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2422788-A2 | Benzodiazepines and compositions and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-11-27 | — | — | US | disclosed |
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293700-A1 | Compositions and Methods Relating to Novel Compounds and Targets Thereof | BAX, BAD, GABRB3 | OPRK1 111/4885LMNA 2518/4885PDE3A 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.