SCHEMBL10149677

SCHEMBL10149677

Nc1ncnn2c(Br)cnc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 2/20 0.35
PI4K2B Q8TCG2 2/20 0.35
PI4K2A Q9BTU6 2/20 0.35
PI4KB Q9UBF8 2/20 0.35
ABL1 P00519 1/20 0.34
KDR P35968 1/20 0.34
ADORA2A P29274 4/20 0.33
ADORA1 P30542 4/20 0.33
ADORA2B P29275 3/20 0.33
MAP4K4 O95819 1/20 0.32
ADORA3 P0DMS8 2/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
EGFR P00533 1/20 0.31
CYP1A2 P05177 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22326722 0.79 PI4KA (0.37) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL10120458 0.76 PI4KA (0.39) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL23679750 0.76 PI4KA (0.35) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL275109 0.75 XDH (0.32)
SCHEMBL21539219 0.73 PI4KA (0.33) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL31329908 0.72 HRH4 (0.33) ABL1KDRMAP4K4
SCHEMBL21636967 0.72 TLR7 (0.39) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL21943279 0.72 PI4KA (0.36) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL23476726 0.72 ENPP1 (0.40) PI4KAPI4K2BPI4K2API4KBADORA2A
SCHEMBL24075457 0.72 PI4KA (0.36) PI4KAPI4K2BPI4K2API4KBADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118767697-B Porous membrane for asymmetric all-vanadium redox flow battery and preparation method thereof 杭州德海艾科能源科技有限公司 2024-11-19 CN claimed
CN-118767697-A Porous membrane for asymmetric all-vanadium redox flow battery and preparation method thereof 杭州德海艾科能源科技有限公司 2024-10-15 CN claimed
US-12516065-B2 Tertiary alcohols as PI3K-γ inhibitors INCYTE CORPORATION (US) 2026-01-06 US disclosed
EP-4593836-A2 HETEROCYCLES AS MODULATORS OF NSD ACTIVITY Board of Regents, The University of Texas System (US) 2025-08-06 EP disclosed
US-20250243209-A1 HETEROCYCLES AS MODULATORS OF NSD ACTIVITY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-07-31 US disclosed
CN-119894513-A Heterocycles as modulators of NSD activity 德州大学系统董事会 2025-04-25 CN disclosed
CN-118767697-B Porous membrane for asymmetric all-vanadium redox flow battery and preparation method thereof 杭州德海艾科能源科技有限公司 2024-11-19 CN disclosed
CN-118767697-A Porous membrane for asymmetric all-vanadium redox flow battery and preparation method thereof 杭州德海艾科能源科技有限公司 2024-10-15 CN disclosed
US-12102648-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2024-10-01 US disclosed
US-20240228498-A1 TERTIARY ALCOHOLS AS PI3K-y INHIBITORS INCYTE CORPORATION 2024-07-11 US disclosed
US-12030885-B2 Substituted imidazo[2,1-f][1,2,4]triazines as PI3K-gamma inhibitors INCYTE CORPORATION (US) 2024-07-09 US disclosed
CN-104086553-A Method for preparing 7-bromoimidazo[2,1-f][1,2,4]triazin-4-amine PHARMABLOCK NANJING R & D CO LTD 2014-10-08 CN disclosed
CN-104086553-A Method for preparing 7-bromoimidazo[2,1-f][1,2,4]triazin-4-amine PHARMABLOCK NANJING R & D CO LTD 2014-10-08 CN disclosed
WO-2014035140-A2 COMPOUNDS AND COMPOSITIONS FOR MODULATING HISTONE METHYLTRANSFERASE ACTIVITY KAINOS MEDICINE, INC. (KR) 2014-03-06 WO disclosed
US-8455451-B2 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment GILEAD SCIENCES, INC. (US) 2013-06-04 US disclosed
US-8455451-B2 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment GILEAD SCIENCES, INC. (US) 2013-06-04 US disclosed
WO-2012039791-A1 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT GILEAD SCIENCES, INC. (US) 2012-03-29 WO disclosed
WO-2012039787-A1 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT GILEAD SCIENCES, INC. (US) 2012-03-29 WO disclosed
US-20120009147-A1 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT GILEAD SCIENCES, INC. (US) 2012-01-12 US disclosed
US-20120009147-A1 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT GILEAD SCIENCES, INC. (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120009147-A1 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT PNP, NSUN2, CDA PI4KA 153/4885PI4K2B 192/4885PI4K2A 103/4885
US-12030885-B2 Substituted imidazo[2,1-f][1,2,4]triazines as PI3K-gamma inhibitors PIK3CG, PIK3CD, PIK3R5 PI4KA 5/4885PI4K2B 13/4885PI4K2A 14/4885
US-20240228498-A1 TERTIARY ALCOHOLS AS PI3K-y INHIBITORS PIK3R5, PIK3R1, PIK3CD PI4KA 13/4885PI4K2B 20/4885PI4K2A 27/4885
US-12102648-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP PI4KA 3661/4885PI4K2B 3223/4885PI4K2A 3497/4885
US-20250243209-A1 HETEROCYCLES AS MODULATORS OF NSD ACTIVITY NSD3, NCOA1, NR1D1 PI4KA 4249/4885PI4K2B 4125/4885PI4K2A 4339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.