SCHEMBL10150902

SCHEMBL10150902

CNC(=O)c1cc(C(=O)OC)cc(C)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ccccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
USP2 O75604 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
SLC16A3 O15427 6/20 0.33
SLC16A1 P53985 5/20 0.33
IDH1 O75874 1/20 0.32
P2RY1 P47900 1/20 0.32
SMURF1 Q9HCE7 1/20 0.31
POLB P06746 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
TP53 P04637 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10150908 0.91 IDH1 (0.33) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL13090573 0.91 CNR2 (0.34) ALDH1A1SLC16A3SLC16A1IDH1SMURF1
SCHEMBL10124122 0.90 DHODH (0.34) KDM4EUSP2ALDH1A1TSHRHSD17B10
SCHEMBL19465266 0.90 IDH1 (0.33) KDM4EUSP2ALDH1A1TSHRHSD17B10
SCHEMBL685551 0.87 IDH1 (0.32) ALDH1A1IDH1MEN1KMT2ANPC1
SCHEMBL10083881 0.87 SLC2A1 (0.35) IDH1MEN1KMT2A
SCHEMBL13085374 0.87 RXRA (0.36) ALDH1A1IDH1
SCHEMBL10150904 0.87 POLB (0.34) KDM4EHSD17B10SLC16A3SLC16A1IDH1
SCHEMBL10151093 0.86 NPC1 (0.35) SLC16A3SLC16A1IDH1POLBMEN1
SCHEMBL10150934 0.86 POLB (0.34) ALDH1A1SLC16A3SLC16A1IDH1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9790202-B2 Anthranilamide derivatives as pesticides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-10-17 US disclosed
US-20120010250-A1 Anthranilamide derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010250-A1 Anthranilamide derivatives as pesticides ANTXR2, NQO2, AADAC KDM4E 1453/4885USP2 3434/4885ALDH1A1 1163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.