SCHEMBL10150908

SCHEMBL10150908

CNC(=O)c1cc(C(N)=S)cc(C)c1NC(=O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ccccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.33
SLC2A1 P11166 1/20 0.31
SLC2A3 P11169 1/20 0.31
SLC2A4 P14672 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
BRD4 O60885 1/20 0.30
F2 P00734 1/20 0.30
F10 P00742 1/20 0.30
PRSS1 P07477 1/20 0.30
PRSS2 P07478 1/20 0.30
PRSS3 P35030 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17146132 0.94 SLC2A1 (0.33) IDH1SLC2A1SLC2A3SLC2A4MEN1
SCHEMBL10150902 0.91 KDM4E (0.33) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL13090573 0.90 CNR2 (0.34) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL10124212 0.90 SLC2A1 (0.33) SLC2A1SLC2A3SLC2A4
SCHEMBL13085374 0.87 RXRA (0.36) IDH1F2F10
SCHEMBL10083881 0.87 SLC2A1 (0.35) IDH1SLC2A1SLC2A3SLC2A4MEN1
SCHEMBL685551 0.87 IDH1 (0.32) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL10150934 0.85 POLB (0.34) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL10151093 0.85 NPC1 (0.35) IDH1MEN1KMT2ANPC1RAB9A
SCHEMBL10150903 0.85 POLB (0.33) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9790202-B2 Anthranilamide derivatives as pesticides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-10-17 US disclosed
US-20120010250-A1 Anthranilamide derivatives as pesticides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010250-A1 Anthranilamide derivatives as pesticides ANTXR2, NQO2, AADAC IDH1 332/4885SLC2A1 4752/4885SLC2A3 4671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.