Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016283 | 0.99 | KDM4E (0.52) | KDM4EHSD17B10SERPINE1PTPN1GRIK1 | |
| SCHEMBL1015774 | 0.87 | ALDH1A1 (0.43) | RXFP1MAPTTDP1ALDH1A1 | |
| SCHEMBL1015129 | 0.87 | MAPT (0.42) | SERPINE1PPARGPPARARXFP1MAPT | |
| SCHEMBL1015626 | 0.86 | RXFP1 (0.53) | KDM4EHSD17B10SERPINE1RXFP1MAPT | |
| SCHEMBL417503 | 0.84 | MAPT (0.64) | KDM4EHSD17B10SERPINE1RXFP1MAPT | |
| SCHEMBL1018976 | 0.78 | PTPN1 (0.52) | KDM4EPTPN1MAPTALDH1A1 | |
| SCHEMBL1016253 | 0.78 | RXFP1 (0.45) | KDM4EHSD17B10SERPINE1PTPN1RXFP1 | |
| SCHEMBL1016816 | 0.77 | RXFP1 (0.46) | KDM4EHSD17B10SERPINE1PTPN1RXFP1 | |
| SCHEMBL1015634 | 0.76 | ALDH1A1 (0.53) | KDM4ERXFP1MAPTTDP1ALDH1A1 | |
| SCHEMBL7037646 | 0.75 | PPARG (0.65) | KDM4ESERPINE1GRIK1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990057-B1 | PAI-1 INHIBITOR FOR USE IN ENHANCING THE ANTITUMOR EFFECT OF AN ANTITUMOR AGENT IN A PATIENT | RENASCIENCE CO LTD (JP) | 2019-03-20 | — | — | EP | disclosed |
| EP-2990057-A1 | NOVEL USE FOR PAI-1 INHIBITOR | Renascience Co., Ltd. (JP) | 2016-03-02 | — | — | EP | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |