Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646580 | 0.95 | DEGS1 (0.45) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL648016 | 0.93 | LIPE (0.43) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL8234419 | 0.92 | DEGS1 (0.47) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL648772 | 0.92 | F10 (0.42) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL645596 | 0.92 | MEN1 (0.44) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL646827 | 0.92 | MAPT (0.41) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL646984 | 0.91 | TP53 (0.43) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL649267 | 0.91 | DEGS1 (0.40) | DEGS1HPGDSEPHX2ALDH1A1GAA | |
| SCHEMBL648071 | 0.90 | MAPT (0.44) | DEGS1HPGDSALDH1A1GAAPOLB | |
| SCHEMBL646895 | 0.90 | HPGDS (0.41) | DEGS1HPGDSEPHX2ALDH1A1RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |