Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645446 | 0.91 | ABCB1 (0.44) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL645416 | 0.90 | NPC1 (0.44) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL14400700 | 0.90 | RAB9A (0.39) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL648285 | 0.89 | KMT2A (0.46) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL649492 | 0.89 | NPC1 (0.51) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL645754 | 0.87 | HPGDS (0.40) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL647532 | 0.86 | NPC1 (0.41) | RAB9ANPC1TP53GAAKMT2A | |
| SCHEMBL8234095 | 0.86 | NPC1 (0.55) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL645960 | 0.86 | NPC1 (0.46) | RAB9ANPC1MITFTP53GAA | |
| SCHEMBL646333 | 0.86 | NPC1 (0.46) | RAB9ANPC1TP53GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119643-B2 | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2012-02-21 | — | — | US | disclosed |