Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | PPARG | P37231 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723083 | 0.87 | PPARG (0.57) | NPC1RAB9APPARGPPARAMAPT | |
| SCHEMBL2717815 | 0.84 | ALDH1A1 (0.50) | NPC1RAB9APPARGPPARAMAPT | |
| SCHEMBL2401146 | 0.82 | PPARG (0.52) | NPC1RAB9APPARGPPARAMAPT | |
| SCHEMBL2718896 | 0.76 | KMT2A (0.47) | NPC1RAB9APPARGPPARAMAPT | |
| SCHEMBL3011416 | 0.75 | NPC1 (0.44) | NPC1RAB9AALDH1A1KMT2ALMNA | |
| SCHEMBL11871660 | 0.72 | NPC1 (0.42) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL4785028 | 0.72 | NPC1 (0.48) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL845348 | 0.72 | NPSR1 (0.79) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL4739140 | 0.71 | KMT2A (0.45) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL30543414 | 0.71 | SRD5A2 (0.50) | NPC1RAB9AMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1647546-B1 | NOVEL HETEROARYL DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO (JP) | 2012-05-02 | — | — | EP | disclosed |