Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 12/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729935 | 0.89 | EGFR (0.53) | RECQLEGFRERBB2EPHX2PPARG | |
| SCHEMBL215702 | 0.89 | EGFR (0.53) | RECQLEGFRERBB2EPHX2PPARG | |
| Hydrochloric Acid SCHEMBL1353996 | 0.88 | EGFR (0.52) | EGFRERBB2EPHX2PPARG | |
| SCHEMBL4479748 | 0.84 | RECQL (0.66) | RECQLHTR2AHTR2CEGFRERBB2 | |
| SCHEMBL16044107 | 0.84 | FGFR1 (0.53) | RECQLGRIN1GRIN2BHTR2AHTR2C | |
| SCHEMBL30373336 | 0.83 | RECQL (0.69) | RECQLGRIN1GRIN2BEGFRERBB2 | |
| SCHEMBL2330379 | 0.83 | RECQL (0.69) | RECQLGRIN1GRIN2BEGFRERBB2 | |
| SCHEMBL25413232 | 0.80 | EPHX2 (0.52) | RECQLGRIN1GRIN2BL3MBTL1EPHX2 | |
| SCHEMBL30614165 | 0.80 | EPHX2 (0.52) | RECQLGRIN1GRIN2BL3MBTL1EPHX2 | |
| SCHEMBL27638905 | 0.77 | RECQL (0.69) | RECQLERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001890-B1 | TETRAHYDROPYRIDOTHIENOPYRIMIDINE COMPOUNDS AND USE FOR THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | BAYER SCHERING PHARMA AG (DE) | 2011-01-12 | — | — | EP | disclosed |