Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29992643 | 0.88 | RECQL (0.66) | RECQLBRD4TSHRKDM4CCNR1 | |
| SCHEMBL870390 | 0.88 | RECQL (0.66) | RECQLBRD4TSHRKDM4CCNR1 | |
| SCHEMBL1015246 | 0.84 | RECQL (0.47) | RECQLERBB2EGFRHTR2AHTR2C | |
| SCHEMBL30694932 | 0.81 | RECQL (0.66) | RECQLBRD4TSHRKDM4CERBB2 | |
| SCHEMBL18558982 | 0.81 | RECQL (0.66) | RECQLBRD4TSHRKDM4CERBB2 | |
| SCHEMBL12930779 | 0.81 | RECQL (0.66) | RECQLBRD4TSHRKDM4CERBB2 | |
| SCHEMBL4215903 | 0.81 | RECQL (0.66) | RECQLBRD4TSHRKDM4CALDH1A1 | |
| SCHEMBL2543455 | 0.81 | RECQL (0.66) | RECQLBRD4TSHRKDM4CERBB2 | |
| SCHEMBL4831197 | 0.81 | RECQL (0.75) | RECQLTSHRERBB2ALDH1A1KMO | |
| SCHEMBL5863967 | 0.81 | TDP1 (0.56) | RECQLBRD4TSHRCNR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3676255-B1 | THERAPEUTIC INDAZOLES | RUTGERS THE STATE UNIV UNIV OF NEW JERSEY (US) | 2025-04-16 | — | — | EP | disclosed |
| US-12060330-B2 | Therapeutic indazoles | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-08-13 | — | — | US | disclosed |
| CN-111479805-B | Therapeutic indazoles | 罗格斯新泽西州立大学 | 2024-08-13 | — | — | CN | disclosed |
| US-20220144781-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-05-12 | — | — | US | disclosed |
| US-11186549-B2 | Therapeutic indazoles | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2021-11-30 | — | — | US | disclosed |
| CN-111479805-A | Therapeutic indazoles | 罗格斯新泽西州立大学 | 2020-07-31 | — | — | CN | disclosed |
| EP-3676255-A1 | THERAPEUTIC INDAZOLES | Rutgers, The State University University Of New Jersey (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20200199076-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-06-25 | — | — | US | disclosed |
| WO-2019046467-A1 | THERAPEUTIC INDAZOLES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-03-07 | — | — | WO | disclosed |
| EP-2817310-B1 | 8-SUBSTITUTED 2-AMINO-[1,2,4]TRIAZOLO[1,5-A]PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2018-03-21 | — | — | EP | disclosed |
| US-5440035-A | Leukotriene antagonists; antiallergens, antiinflammatory agents | ZENECA INC. (GB) | 1995-08-08 | — | — | US | disclosed |
| US-5391758-A | Leukotriene antagonists | ZENECA, INC. (US) | 1995-02-21 | — | — | US | disclosed |
| US-5338734-A | Leukotriene antagonist properties; antiinflammatory agents | ZENECA INC. (US) | 1994-08-16 | — | — | US | disclosed |
| US-5179112-A | Leukotriene antagonist as antiallergens and antiinflammatory agents | ICI AMERICAS INC. (US) | 1993-01-12 | — | — | US | disclosed |
| CN-1017425-B | Process for preparing heterocyclic amide derivatives | ICI AMERICA INC (US) | 1992-07-15 | — | — | CN | disclosed |
| EP-0199543-B1 | HETEROCYCLIC AMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-12-04 | — | — | EP | disclosed |
| US-5030643-A | Antiallergens, antiinflammatory agents | ICI AMERICAS INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-4859692-A | Heterocyclic amide derivatives and pharmaceutical use | ICI AMERICAS INC. (US) | 1989-08-22 | — | — | US | disclosed |
| CN-86103278-A | The method for preparing heterocyclic amide derivative | — | 1986-12-17 | — | — | CN | disclosed |
| EP-0199543-A2 | Heterocyclic amide derivatives | ICI AMERICAS INC. (US) | 1986-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12060330-B2 | Therapeutic indazoles | RIF1, QTRT1, NQO2 | RECQL 377/4885BRD4 217/4885TSHR 66/4885 |
| US-20220144781-A1 | THERAPEUTIC INDAZOLES | RIF1, QTRT1, NQO2 | RECQL 377/4885BRD4 217/4885TSHR 66/4885 |
| US-20200199076-A1 | THERAPEUTIC INDAZOLES | RIF1, NQO2, QTRT1 | RECQL 341/4885BRD4 262/4885TSHR 105/4885 |
| US-11186549-B2 | Therapeutic indazoles | RIF1, NQO2, QTRT1 | RECQL 341/4885BRD4 262/4885TSHR 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.