Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.62 |
| ▸ | UBE2I | P63279 | 2/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015171 | 0.91 | SERPINE1 (0.75) | SERPINE1UBE2ICACNA1BAPBA1SAE1 | |
| SCHEMBL1015063 | 0.87 | SERPINE1 (0.58) | SERPINE1UBE2ICACNA1BAPBA1SAE1 | |
| SCHEMBL1016295 | 0.87 | LCLAT1 (0.49) | SERPINE1LMNATHRBKDM4EALDH1A1 | |
| SCHEMBL1015802 | 0.86 | SERPINE1 (0.84) | SERPINE1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL417150 | 0.83 | SERPINE1 (0.60) | SERPINE1LMNATHRBKDM4EALDH1A1 | |
| SCHEMBL1015659 | 0.82 | SERPINE1 (0.60) | SERPINE1THRBKDM4EPOLBL3MBTL1 | |
| SCHEMBL1015851 | 0.82 | SERPINE1 (0.58) | SERPINE1LMNAKDM4EL3MBTL1MAPT | |
| SCHEMBL1015404 | 0.82 | SERPINE1 (0.58) | SERPINE1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL1017187 | 0.82 | SERPINE1 (0.57) | SERPINE1KDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL1015852 | 0.82 | SERPINE1 (0.57) | SERPINE1LMNATHRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415479-B2 | Inhibitor of plasminogen activator inhibitor-1 | RENASCIENCE CO., LTD. (JP) | 2013-04-09 | — | — | US | disclosed |
| US-20110112140-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | RENASCIENCE CO., LTD. (JP) | 2011-05-12 | — | — | US | disclosed |
| EP-2272822-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Renascience CO., LTD. (JP) | 2011-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112140-A1 | INHIBITOR OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | SERPINE1, SERPINB1, SERPINC1 | SERPINE1 1/4885UBE2I 2656/4885CACNA1B 4702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.