Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153304 | 1.00 | CALCA (0.59) | CALCACALCRL | |
| SCHEMBL1393838 | 0.90 | CALCA (0.60) | CALCACALCRL | |
| SCHEMBL1393840 | 0.90 | CALCA (0.60) | CALCACALCRL | |
| SCHEMBL12049267 | 0.89 | CALCA (0.59) | CALCACALCRL | |
| SCHEMBL12048960 | 0.89 | CALCRL (0.56) | CALCACALCRL | |
| SCHEMBL3526508 | 0.84 | CALCA (0.63) | CALCACALCRL | |
| SCHEMBL10189878 | 0.84 | CALCA (0.63) | CALCACALCRL | |
| SCHEMBL1394658 | 0.84 | CALCA (0.63) | CALCACALCRL | |
| SCHEMBL1393888 | 0.84 | CALCA (0.63) | CALCACALCRL | |
| SCHEMBL3526238 | 0.84 | CALCA (0.54) | CALCACALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140275017-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | US | disclosed |
| US-8778957-B2 | CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20120010193-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275017-A1 | CGRP RECEPTOR ANTAGONISTS | BDKRB1, CALCRL, BDKRB2 | CALCA 12/4885CALCRL 2/4885 |
| US-20120010193-A1 | CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CALCRL | CALCA 13/4885CALCRL 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.