SCHEMBL10153618

SCHEMBL10153618

COc1cc(-c2c3ccccc3c(-c3ccc4c(c3)C(C)(C)c3cc(-c5ccc6c(c5)C(C)(C)c5cc(-c7c8ccccc8c(-c8c9ccccc9c(-c9ccc%10c(c9)C(C)(C)c9ccccc9-%10)c9ccccc89)c8ccccc78)ccc5-6)ccc3-4)c3ccccc23)ccc1-c1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.43
ACACA Q13085 2/20 0.41
DHODH Q02127 1/20 0.37
LMNA P02545 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PDCD1 Q15116 1/20 0.35
CD274 Q9NZQ7 1/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
AAK1 Q2M2I8 1/20 0.35
GAK O14976 1/20 0.35
MAPT P10636 1/20 0.35
CYP1A1 P04798 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2E1 P05181 1/20 0.35
CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14600487 0.96 ACACA (0.44) PDK2ACACADHODHLMNAHPGD
SCHEMBL10153567 0.86 PDK2 (0.41) PDK2ACACADHODHLMNASMN1; SMN2
SCHEMBL10153264 0.85 PDK2 (0.40) PDK2ACACALMNASMN1; SMN2ALDH1A1
SCHEMBL10153211 0.85 PDK2 (0.40) PDK2ACACALMNASMN1; SMN2ALDH1A1
SCHEMBL10153505 0.85 PDK2 (0.41) PDK2ACACADHODHLMNASMN1; SMN2
SCHEMBL10153306 0.85 PDK2 (0.41) PDK2ACACADHODHLMNASMN1; SMN2
SCHEMBL10154023 0.84 PDK2 (0.41) PDK2ACACALMNASMN1; SMN2ALDH1A1
SCHEMBL14600375 0.84 PDK2 (0.41) PDK2ACACALMNASMN1; SMN2PDCD1
SCHEMBL10153672 0.84 PDK2 (0.51) PDK2ACACALMNAHPGDSMN1; SMN2
SCHEMBL10153542 0.84 PDK2 (0.51) PDK2ACACALMNAHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1221434-B1 HYDROCARBON COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT MITSUI CHEMICALS INC (JP) 2012-06-27 EP disclosed
US-7166240-B2 Hydrocarbon compounds, materials for organic electroluminescent elements and organic electroluminescent elements MITSUI CHEMICALS, INC. (JP) 2007-01-23 US disclosed
US-7166240-B2 Hydrocarbon compounds, materials for organic electroluminescent elements and organic electroluminescent elements MITSUI CHEMICALS, INC. (JP) 2007-01-23 US disclosed