⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264685 | 0.84 | — | — | |
| SCHEMBL12162166 | 0.79 | NOS1 (0.36) | — | |
| SCHEMBL2965185 | 0.77 | TRIM24 (0.37) | — | |
| SCHEMBL7639721 | 0.77 | TRIM24 (0.37) | — | |
| SCHEMBL1816717 | 0.74 | TRIM24 (0.35) | — | |
| SCHEMBL11227221 | 0.74 | — | — | |
| SCHEMBL31629212 | 0.74 | NCF1 (0.37) | — | |
| SCHEMBL87369 | 0.72 | — | — | |
| SCHEMBL6591999 | 0.72 | — | — | |
| SCHEMBL20485310 | 0.72 | NCF1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127944-A1 | BROAD-SPECTRUM CARBAPENEMS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-04-27 | — | — | US | disclosed |
| US-20230127944-A1 | BROAD-SPECTRUM CARBAPENEMS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-04-27 | — | — | US | disclosed |
| WO-2021101620-A1 | BROAD-SPECTRUM CARBAPENEMS | VenatoRx Pharmaceuticals, Inc. (US) | 2021-05-27 | — | — | WO | disclosed |
| US-20200115357-A1 | LIVER X RECEPTORS (LXR) MODULATORS | PHENEX-FXR GMBH (DE) | 2020-04-16 | — | — | US | disclosed |
| EP-3609880-A1 | LIVER X RECEPTORS (LXR) MODULATORS | Phenex-FXR GmbH (DE) | 2020-02-19 | — | — | EP | disclosed |
| CN-110546144-A | Liver X Receptor (LXR) modulators | PHENEX FXR GMBH | 2019-12-06 | — | — | CN | disclosed |
| WO-2018188795-A1 | LIVER X RECEPTORS (LXR) MODULATORS | PHENEX-FXR GMBH (DE) | 2018-10-18 | — | — | WO | disclosed |
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |