Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954755 | 0.82 | S1PR2 (0.56) | SMN1; SMN2L3MBTL1S1PR2S1PR1S1PR3 | |
| SCHEMBL13408004 | 0.82 | LMNA (0.53) | LOXL2SMN1; SMN2L3MBTL1S1PR2S1PR1 | |
| SCHEMBL347332 | 0.81 | ALDH1A1 (0.60) | ALDH1A1RECQLNR1I2CYP3A4SMN1; SMN2 | |
| Water SCHEMBL29229746 | 0.81 | ALDH1A1 (0.71) | ALDH1A1RECQLNR1I2CYP3A4SMN1; SMN2 | |
| SCHEMBL12954628 | 0.79 | S1PR2 (0.61) | SMN1; SMN2L3MBTL1S1PR2S1PR1S1PR3 | |
| SCHEMBL1240006 | 0.79 | ALDH1A1 (0.48) | ALDH1A1RECQLCYP3A4 | |
| SCHEMBL28106819 | 0.78 | ALDH1A1 (0.75) | ALDH1A1RECQLNR1I2CYP3A4SMN1; SMN2 | |
| SCHEMBL48239 | 0.78 | ALDH1A1 (0.75) | ALDH1A1RECQLNR1I2CYP3A4SMN1; SMN2 | |
| SCHEMBL17192651 | 0.78 | S1PR2 (0.63) | L3MBTL1S1PR2S1PR1S1PR3LPAR2 | |
| SCHEMBL14452030 | 0.78 | HRH3 (0.66) | ALDH1A1SMN1; SMN2LMNAMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-06-28 | — | — | US | disclosed |
| EP-2397479-A1 | HETERO RING DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092962-A1 | HETERO RING DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165309-A1 | HETERO RING DERIVATIVE | IL2, PIK3R2, IL2RA | ALDH1A1 3496/4885RECQL 4243/4885NR1I2 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.