Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.39 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14642742 | 1.00 | POLRMT (0.39) | POLRMTDOT1LMAP4K4STING1ACVRL1 | |
| SCHEMBL21120506 | 1.00 | POLRMT (0.39) | POLRMTDOT1LMAP4K4STING1ACVRL1 | |
| SCHEMBL13532219 | 0.87 | DOT1L (0.37) | POLRMTDOT1LMAP4K4STING1ACVRL1 | |
| SCHEMBL13696066 | 0.87 | DOT1L (0.37) | POLRMTDOT1LMAP4K4STING1ACVRL1 | |
| SCHEMBL20058766 | 0.87 | DOT1L (0.37) | POLRMTDOT1LMAP4K4STING1ACVRL1 | |
| SCHEMBL23960108 | 0.83 | POLRMT (0.47) | POLRMT | |
| SCHEMBL24123639 | 0.82 | DOT1L (0.36) | POLRMTDOT1LSTING1RIPK1 | |
| SCHEMBL18520016 | 0.82 | STING1 (0.35) | DOT1LSTING1ACVRL1ADORA3ADORA2A | |
| SCHEMBL23960103 | 0.81 | DOT1L (0.38) | POLRMTDOT1LSTING1RIPK1 | |
| SCHEMBL14642598 | 0.81 | ADRB1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3505173-B1 | PYRROLO[1,2-F][1,2,4]TRIAZINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES INC (US) | 2022-07-06 | — | — | EP | disclosed |
| WO-2021213288-A1 | ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG | 中国科学院上海药物研究所 (CN) | 2021-10-28 | — | — | WO | disclosed |
| WO-2012012776-A1 | METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2009132135-A1 | 1' -SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2009-10-29 | — | — | WO | disclosed |