Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121240 | 0.81 | EPHX2 (0.41) | CYP2D6CYP2C19EPHX2RECQLEPHX1 | |
| SCHEMBL9951281 | 0.79 | EPHX1 (0.44) | EPHX2EPHX1 | |
| SCHEMBL10155108 | 0.78 | MCL1 (0.39) | EPHX2EPHX1ALDH1A1MMP1MMP8 | |
| SCHEMBL22941133 | 0.76 | CYP2D6 (0.46) | CYP2D6CYP2C19EPHX2RECQLEPHX1 | |
| SCHEMBL22021747 | 0.73 | EPHX2 (0.39) | CYP2D6CYP2C19EPHX2RECQLEPHX1 | |
| SCHEMBL8847934 | 0.72 | CTSD (0.56) | EPHX2EPHX1HPGDMMP1MMP8 | |
| SCHEMBL10447542 | 0.71 | CYP2D6 (0.62) | CYP2D6CYP2C19RECQLEPHX1ALDH1A1 | |
| SCHEMBL22947022 | 0.71 | EPHX2 (0.36) | CYP2D6CYP2C19EPHX2RECQLEPHX1 | |
| SCHEMBL10381056 | 0.69 | CYP2D6 (0.52) | CYP2D6CYP2C19EPHX2RECQLEPHX1 | |
| SCHEMBL7660375 | 0.68 | RECQL (0.43) | CYP2D6CYP2C19EPHX2RECQLEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101643-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100233122-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100233122-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | EIF2AK2, ZC3HAV1, HAVCR2 | CYP2D6 497/4885CYP2C19 180/4885EPHX2 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.