Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22941133 | 0.86 | CYP2D6 (0.46) | RECQLKDM4EALDH1A1GAACTSD | |
| SCHEMBL8847934 | 0.81 | CTSD (0.56) | CTSDEPHX1HPGDPOLBEPHX2 | |
| SCHEMBL21661078 | 0.77 | CYP2C19 (0.45) | RECQLKDM4ECTSDEPHX1CYP2D6 | |
| SCHEMBL9872315 | 0.73 | ALDH1A1 (0.52) | RECQLKDM4EALDH1A1EPHX1HPGD | |
| SCHEMBL13226914 | 0.70 | TLR4 (0.36) | ALDH1A1POLB | |
| SCHEMBL337416 | 0.69 | BRD4 (0.50) | ALDH1A1GAAHSD17B10POLBEPHX2 | |
| SCHEMBL9998181 | 0.69 | KMT2A (0.42) | ALDH1A1GAAEPHX1EPHX2SMN1; SMN2 | |
| SCHEMBL29210816 | 0.69 | CYP2D6 (0.38) | ALDH1A1CYP2D6HPGDLMNASMN1; SMN2 | |
| SCHEMBL21047642 | 0.69 | SMYD3 (0.38) | KDM4EEPHX1CYP2D6LMNA | |
| SCHEMBL10154838 | 0.68 | CYP2D6 (0.43) | RECQLKDM4EALDH1A1GAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6384065-B1 | CONTROL THE FUNCTIONS OF PROTEINS SUCH AS ENZYMES AND RECEPTOR FORTREATING INFLAMMATORY DISEASES SUCH AS RHEUMATOID ARTHRITIS, | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-1076056-A1 | NOVEL SPIRO COMPOUNDS OR SALTS THEREOF AND PREVENTIVES/REMEDIES FOR AUTOIMMUNE DISEASES AND AP-1 INHIBITORS CONTAINING THE SAME | TOYAMA CHEMICAL CO., LTD. (JP) | 2001-02-14 | — | — | EP | disclosed |