Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 15/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298946 | 0.89 | ALK (0.52) | PLK1BRD4ALK | |
| SCHEMBL10129427 | 0.81 | EML4 (0.59) | BRD4ALKFLT3 | |
| SCHEMBL283519 | 0.78 | BRD4 (0.49) | BRD4ALKEGFRFLT3 | |
| SCHEMBL10126815 | 0.77 | ALK (0.54) | BRD4ALKEGFR | |
| SCHEMBL17690587 | 0.76 | SLC2A1 (0.58) | BRD4ALKEGFRFLT3 | |
| SCHEMBL29245012 | 0.75 | ALDH1A1 (0.62) | — | |
| SCHEMBL29390384 | 0.75 | BRD4 (0.73) | PLK1BRD4ALKEGFRFLT3 | |
| SCHEMBL28711724 | 0.75 | BRD4 (0.73) | PLK1BRD4ALKEGFRFLT3 | |
| SCHEMBL10169167 | 0.74 | SYK (0.56) | BRD4ALKFLT3 | |
| SCHEMBL18296155 | 0.74 | LCK (0.73) | ALKEGFRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | WATERS TECHNOLOGIES CORPORATION (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | EML4, ALK, ERBB4 | PLK1 1966/4885BRD4 32/4885ALK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.