Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 16/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473362 | 0.82 | RPS6KB1 (0.39) | OPRM1RPS6KB1LRRK2STK4STK3 | |
| SCHEMBL2363683 | 0.81 | RPS6KB1 (0.37) | OPRM1RPS6KB1LRRK2STK4STK3 | |
| SCHEMBL10158494 | 0.81 | RPS6KB1 (0.35) | RPS6KB1 | |
| SCHEMBL473394 | 0.76 | RPS6KB1 (0.59) | RPS6KB1 | |
| SCHEMBL10157820 | 0.75 | AKT2 (0.40) | RPS6KB1 | |
| SCHEMBL473326 | 0.71 | RPS6KB1 (0.39) | RPS6KB1LRRK2STK4STK3 | |
| SCHEMBL1791832 | 0.70 | RPS6KB1 (0.39) | RPS6KB1 | |
| SCHEMBL1791436 | 0.68 | MAPT (0.58) | LRRK2STK4STK3 | |
| SCHEMBL1788366 | 0.67 | ABCB1 (0.48) | RPS6KB1 | |
| SCHEMBL473458 | 0.67 | RPS6KB1 (0.37) | RPS6KB1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | disclosed |