Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 16/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473362 | 0.91 | RPS6KB1 (0.39) | RPS6KB1OPRM1LRRK2STK4STK3 | |
| SCHEMBL10159660 | 0.81 | OPRM1 (0.36) | RPS6KB1OPRM1LRRK2STK4STK3 | |
| SCHEMBL473326 | 0.79 | RPS6KB1 (0.39) | RPS6KB1LRRK2STK4STK3 | |
| SCHEMBL1791832 | 0.78 | RPS6KB1 (0.39) | RPS6KB1 | |
| SCHEMBL15252580 | 0.76 | AKT2 (0.41) | RPS6KB1 | |
| SCHEMBL473394 | 0.76 | RPS6KB1 (0.59) | RPS6KB1 | |
| SCHEMBL473299 | 0.74 | RPS6KB1 (0.65) | RPS6KB1LRRK2 | |
| SCHEMBL473458 | 0.73 | RPS6KB1 (0.37) | RPS6KB1LRRK2 | |
| SCHEMBL473316 | 0.72 | AKT2 (0.41) | RPS6KB1 | |
| SCHEMBL10158494 | 0.68 | RPS6KB1 (0.35) | RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | disclosed |