Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473326 | 0.79 | RPS6KB1 (0.39) | RPS6KB1LRRK2 | |
| SCHEMBL1791832 | 0.76 | RPS6KB1 (0.39) | RPS6KB1MAPT | |
| SCHEMBL473394 | 0.76 | RPS6KB1 (0.59) | RPS6KB1 | |
| SCHEMBL473362 | 0.76 | RPS6KB1 (0.39) | RPS6KB1LRRK2 | |
| SCHEMBL473299 | 0.74 | RPS6KB1 (0.65) | RPS6KB1LRRK2 | |
| SCHEMBL15252580 | 0.71 | AKT2 (0.41) | RPS6KB1 | |
| SCHEMBL1791436 | 0.70 | MAPT (0.58) | LRRK2LMNAMAPT | |
| SCHEMBL473316 | 0.70 | AKT2 (0.41) | RPS6KB1 | |
| SCHEMBL23532535 | 0.68 | AKT2 (0.44) | RPS6KB1 | |
| SCHEMBL10159660 | 0.67 | OPRM1 (0.36) | RPS6KB1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | claimed |