Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 17/20 | 0.51 |
| ▸ | JAK3 | P52333 | 8/20 | 0.47 |
| ▸ | BTK | Q06187 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016371 | 0.90 | ITK (0.48) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL1019330 | 0.86 | ITK (0.45) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL1016016 | 0.85 | ITK (0.56) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL27912552 | 0.84 | ITK (0.53) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL1016370 | 0.76 | SYK (0.55) | ITKJAK3BTKEGFR | |
| SCHEMBL15890554 | 0.76 | MET (0.51) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL27930621 | 0.76 | SYK (0.57) | ITKJAK3BTKEGFRBLK | |
| SCHEMBL4383008 | 0.74 | SYK (0.53) | ITKJAK3BTKEGFR | |
| SCHEMBL1073511 | 0.71 | BUB1 (0.42) | ITKEGFR | |
| SCHEMBL14666818 | 0.71 | SYK (0.64) | ITKJAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |