Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.48 |
| ▸ | BTK | Q06187 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 10/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016017 | 0.90 | ITK (0.51) | ITKBTKJAK3EGFRBLK | |
| SCHEMBL1019330 | 0.87 | ITK (0.45) | ITKBTKJAK3EGFRBLK | |
| SCHEMBL1016370 | 0.85 | SYK (0.55) | ITKBTKJAK3EGFRSYK | |
| SCHEMBL27930621 | 0.85 | SYK (0.57) | ITKBTKJAK3EGFRBLK | |
| SCHEMBL1016016 | 0.77 | ITK (0.56) | ITKBTKJAK3EGFRBLK | |
| SCHEMBL27912552 | 0.77 | ITK (0.53) | ITKBTKJAK3EGFRBLK | |
| SCHEMBL1018254 | 0.76 | CDC7 (0.49) | SYK | |
| SCHEMBL1017789 | 0.76 | JAK3 (0.55) | BTKJAK3EGFRSYKADORA3 | |
| SCHEMBL4383008 | 0.75 | SYK (0.53) | ITKBTKJAK3EGFRSYK | |
| SCHEMBL15890554 | 0.75 | MET (0.51) | ITKBTKJAK3EGFRBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | claimed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |