Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10161340 | 0.88 | THRA (0.42) | HPGDLMNAMAOBALDH1A1HSD17B10 | |
| SCHEMBL10161339 | 0.87 | MRGPRX4 (0.46) | HPGDLMNAMAOBALDH1A1HSD17B10 | |
| SCHEMBL10197010 | 0.85 | PTPN1 (0.40) | HPGDLMNAHSD17B10TSHRPTPN1 | |
| SCHEMBL10161372 | 0.80 | BRD4 (0.40) | HPGDLMNAALDH1A1HSD17B10USP2 | |
| SCHEMBL10161437 | 0.80 | MAPT (0.43) | HPGDLMNAMAOBPTPN1MAPT | |
| SCHEMBL10161447 | 0.78 | TP53 (0.43) | HPGDLMNAMAOBPTPN1MAPT | |
| SCHEMBL10161344 | 0.76 | MAPT (0.51) | HPGDLMNAALDH1A1HSD17B10USP2 | |
| SCHEMBL6125199 | 0.74 | PTPN1 (0.47) | HPGDLMNAMAOBPTPN1NR4A2 | |
| SCHEMBL10196582 | 0.73 | THRA (0.40) | LMNAMAPTKMT2AMEN1MAPK1 | |
| SCHEMBL10102206 | 0.73 | PTPN1 (0.43) | HPGDLMNAMAOBTSHRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115819-A1 | Pentacycline Compounds | TETRAPHASE PHARMACEUTICALS, INC. | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115819-A1 | Pentacycline Compounds | TSLP, IL5, IL17A | HPGD 2132/4885LMNA 3157/4885MAOB 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.