Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10160734 | 0.83 | MAPT (0.44) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL12869440 | 0.82 | MAPT (0.47) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL10161795 | 0.81 | MAPT (0.43) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL10161845 | 0.79 | PIK3CG (0.42) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL12019807 | 0.76 | ALOX5AP (0.39) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL3271282 | 0.74 | DPP4 (0.45) | MAPTLMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL10161766 | 0.73 | ALOX5AP (0.37) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL12019806 | 0.71 | MAPT (0.38) | MAPTLMNAALOX5APMAP4K4EGFR | |
| SCHEMBL5549358 | 0.71 | BMPR1B (0.44) | MAPTLMNAALOX5APATMTLR7 | |
| SCHEMBL9613271 | 0.71 | LMNA (0.52) | MAPTLMNAMAP4K4KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024150-A1 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |