Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 9/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019052 | 0.83 | TTK (0.47) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL4381751 | 0.83 | EGFR (0.50) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL1018622 | 0.82 | TTK (0.52) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL1016309 | 0.81 | TTK (0.51) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL1021471 | 0.78 | PTK2 (0.47) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL1018943 | 0.76 | TTK (0.47) | TTKMAP3K7EGFRJAK3BTK | |
| SCHEMBL1016206 | 0.76 | TTK (0.49) | TTKPTK2MAP3K7EGFRJAK3 | |
| SCHEMBL1017789 | 0.76 | JAK3 (0.55) | TTKPTK2EGFRJAK3BTK | |
| SCHEMBL1015141 | 0.75 | PAK4 (0.59) | TTKEGFRJAK3BTKJAK1 | |
| SCHEMBL4198397 | 0.75 | PDGFRA (0.56) | PTK2EGFRJAK3BTKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271631-A2 | INHIBITORS OF PROTEIN KINASES | Portola Pharmaceuticals, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009131687-A2 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-10-29 | — | — | WO | disclosed |